Proteins fold into amyloid structures with distinct conformations (strains) in neurodegenerative disease. In a new paper published in PNAS, the Condello and Degrado labs developed the EMBER (excitation multiplexed bright emission recording) imaging method to rapidly identify these amyloid conformations in situ... Read more ...
News
Drug-resilient microglia drive sex-dependent phenotypes in tauopathy mice
In a new paper published today in Nature Communications, the IND’s Condello lab found that tau-mediated neurodegeneration is driven by disease-activated... Read more ...
The IND’s Kampmann lab ... Read more ...
The Arnold and Mabel Beckman Foundation announced Dec. 6 an award to a UCSF team comprised of IND faculty Daniel Southworth (Principal Investigator) and Carlo Condello, along with William Degrado, Robert Edwards and David Agard, through its FIB-Milling Sample Preparation for Cellular CryoET program.
The $1.5 million dollar grant will support equipment acquisition and research development for focused ion beam (FIB) milling methodology combined with high-resolution cryo-electron tomography to investigate the cellular ultrastructure associated with neurodegenerative diseases.
For further information on the FIB-Milling Sample Preparation for Cellular CryoET program awards, visit the ... Read more ...