CRISPR_UCSF_Kampmann_IND_PrusinerIND faculty Dr. Martin Kampmann outlines a new strategy to investigate neurodegenerative diseases in a Perspective in press at Trends in Molecular Medicine. He co-developed a research platform based on CRISPR technology that enables activation and repression of each gene in human cells. This platform paves the way for a systematic elucidation of cellular factors that control neurodegeneration. Such factors are potential therapeutic targets in neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease. Read more about research in the Kampmann lab.

Drs. Martin Kampmann and Lisa Gunaydin, both Assistant Professors in the IND, celebrate being named Biohub investigators

IND faculty Dr. Lisa Gunaydin and Dr. Martin Kampmann were named Chan Zuckerberg Biohub Investigators. They are part of the first cohort of 47 scientists from UCSF, Stanford, and Berkeley to join the Biohub.

The Biohub is a nonprofit research organization with the goal to develop new technologies that transform biomedical research. It is funded by a philanthropic investment of $600 million by Facebook founder Mark Zuckerberg and pediatrician Priscilla Chan.

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Vox AD CRISPR Kampmann


The Kampmann Lab's approach of using CRISPR to identify relevant genes, mechanisms, and therapeutic targets in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease was featured in a front page article on Vox. The article presents seven innovative ways in which CRISPR technology will make an impact in 2017.

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Research is First to Suggest That Chronic Traumatic Encephalopathy is a Prion Disease

By Pete Farley (UCSF News Center) on December 02, 2016

A shared biological mechanism may drive the progression of both Alzheimer’s disease (AD) and chronic traumatic encephalopathy (CTE), a neurodegenerative condition associated with repeated concussions and brain trauma, according to a new study led by UC San Francisco scientists.

Both AD and CTE are classified as “tauopathies,” a category of diseases characterized by the improper folding and clumping together of a protein called tau (rhymes with “how”) inside the nerve cells of the brain. The resulting tau aggregates, known as neurofibrillary tangles, are toxic to neurons and are thought to be responsible for the behavioral changes and cognitive decline seen in both disorders.

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