Results Point to ‘Bright Future’ for Understanding Disorder

By Nicholas Weiler on May 3, 2017

Tourette disorder (also known as Tourette syndrome) afflicts as many as one person in a hundred worldwide with potentially disabling symptoms including involuntary motor and vocal tics. However, researchers have so far failed to determine the cause of the disorder, and treatments have only limited effectiveness, in part because the genetics underlying the disorder have remained largely a mystery.

Now, as reported online May 3, 2017, in Neuron, a consortium of top researchers – led by scientists at UC San Francisco, Rutgers University, Massachusetts General Hospital, the University of Florida and Yale School of Medicine – has made a significant advance, identifying the first “high-confidence” risk gene for Tourette disorder as well as three other probable risk... Read more ...

CRISPR_UCSF_Kampmann_IND_PrusinerIND faculty Dr. Martin Kampmann outlines a new strategy to investigate neurodegenerative diseases in a Perspective in press at Trends in Molecular Medicine. He co-developed a research platform based on CRISPR technology that enables activation and repression of each gene in human cells. This platform paves the way for a systematic elucidation of cellular factors that control neurodegeneration. Such factors are potential therapeutic targets in neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease. Read more about research in the Kampmann lab.

Drs. Martin Kampmann and Lisa Gunaydin, both Assistant Professors in the IND, celebrate being named Biohub investigators

IND faculty Dr. Lisa Gunaydin and Dr. Martin Kampmann were named Chan Zuckerberg Biohub Investigators. They are part of the first cohort of 47 scientists from UCSF, Stanford, and Berkeley to join the Biohub.

The Biohub is a nonprofit research organization with the goal to develop new technologies that transform biomedical research. It is funded by a philanthropic investment of $600 million by Facebook founder Mark Zuckerberg and pediatrician Priscilla Chan.

The Biohub is located... Read more ...

Vox AD CRISPR Kampmann


The Kampmann Lab's approach of using CRISPR to identify relevant genes, mechanisms, and therapeutic targets in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease was featured in a front page article on Vox. The article presents seven innovative ways in which CRISPR technology will make an impact in 2017.

Read the article...