Jeremy Willsey, Assistant Professor Institute for Neurodegenerative Diseases University of California, San Francisco

Congratulations to Jeremy Willsey, who received a UCSF Weill Institute for Neurosciences 2017 Trailblazer Award for his proposal titled “Identifying Convergent Molecular Networks in Autism.” The Trailblazer Award Program supports creative, high-risk/high-reward research projects in the neurosciences with the ultimate goal of helping patients by achieving greater understanding of the human brain in health and disease.


CRISPR-based genetic screens are a powerful technology to elucidate disease mechanisms and identify potential therapeutic strategies. However, the experimental design of a successful screen remains a challenge. Graduate student Tamas Nagy and IND faculty Dr. Martin Kampmann developed a simulation tool for these screens, termed CRISPulator, which helps researches to optimize the experimental parameters of different types of CRISPR-based screens. CRISPulator helped to uncover new rules for optimal screen design. The research was published in an article in BMC Bioinformatics:... Read more ...

Kampmann CRISPR UCSFIND faculty Martin Kampmann was featured as an Emerging Investigator in an annual Special Issue of Chemical Communications, the journal by the Royal Society of Chemistry.

He was recognized for his contributions to the development of innovative genetic screening technologies in mammalian cells and their application to identify the target of new drugs. Dr. Kampmann describes this research in a feature article in the same issue (Kampmann, M. [2017] Elucidating drug targets and mechanisms of action by genetic screens in mammalian cells. Chemical Communications 53: 7162–7167... Read more ...

Along with collaborators Mark von Zastrow and Brian Shoichet, IND faculty member Jeremy Willsey was awarded a Bold & Basic grant from the UCSF Quantitative Biosciences Institute to investigate new therapeutic targets for autism spectrum disorder by examining the underlying genetics, networks, and molecular pathways involved in these conditions. Watch a short video about their winning project below. Congrats to the research team!