Kampmann Lab and collaborators identify the molecules mediating the uptake of tau into cells
The prion-like spreading of tau aggregation is thought to drive progression of several neurodegenerative diseases, including Alzheimer’s disease and other so-called “tauopathies”. The mechanisms by which tau aggregates spread between cells are unclear – but an understanding of the specific molecular players may provide us with potential therapeutic targets that inhibit disease progression. The lab of IND faculty Dr. Martin Kampmann collaborated with the groups of Dr. Ken Kosik (UC Santa Barbara) and Dr. Linda Hsieh-Wilson (Caltech) to identify the molecules mediating the uptake of tau into cells: a specific type of sugar on cell surface proteins, 6-O-sulfated... Read more ...