Kampmann Lab, July 2018

A major goal of the Kampmann Lab is the identification of new therapeutic targets for neurodegenerative diseases, such as Alzheimer’s disease. The lab has developed a CRISPR-based screening platform to identify genes and pathways controlling disease processes in neurons and glia from human patient-derived induced pluripotent stem cells. The Innovative Genomics Institute, directed by CRISPR pioneer Dr. Jennifer Doudna, named Dr. Martin Kampmann an IGI Investigator, and supports the Kampmann lab to facilitate the translation of research insights to therapeutic strategies. Kampmann lab members... Read more ...

Keiser Chuang ACS Chemical Biology Machine Learning AI UCSFIn a new “In Focus” article in ACS Chemical Biology, IND Assistant Professor In-Residence Mike Keiser and postdoc Kangway Chuang stress caution when applying machine learning to experimental research models. With new machine learning methods broadly accessible to the research community, Keiser and Chuang emphasize the continued importance of designing strong control experiments and argue that a “hypothesis-driven approach” to research design is “now more critical than ever”.

Read the full abstract and article here

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New Tourette disorder genes come to light

By Michele Solis (UCSF News)

In the largest DNA sequencing study of Tourette Disorder (TD) to date, UC San Francisco researchers and their collaborators have unearthed new data suggesting a potential role for disruptions in cell polarity in the development of this condition. 

In their new study, published online September 25, 2018 in Cell Reports the researchers focused on “de novo” mutations, or rare mutations that arise anew at conception, rather than being inherited from parents... Read more ...

The mission of the Psychiatric Cell Map Initiative (PCMI) is to bridge the gap between the genome and clinic in the field of neuropsychiatric disorder research by systematically mapping the physical and genetic interaction networks underlying these disorders, including autism spectrum disorders, Tourette disorder, epilepsy, intellectual disability, and schizophrenia. This will form a key resource for precision medicine.

NIH funds UCSF-led initiative to chart a course toward new psychiatric drugs

By Dana Smith (UCSF News)

Scientists have struggled for decades to... Read more ...