Eric Tse, PhD
Dr. Eric Tse received his B.S. at UCLA in biochemistry, where he was starting to work in research labs focused on cell signaling, Alzheimer's disease, and the implications of how the innate immune system responds to amyloid beta. He then worked in the lab of Dr. Dan Southworth at the University of Michigan to receive his PhD in biochemistry, where they studied protein homeostasis maintained through a variety of protein chaperone systems. These included the alpha B crystallin system and Hsp90 and HSP70 systems. They also studied how the HSP90 and HSP70 systems and CHIP E3 ubiquitin ligase interact and ubiquitinate tau. Having focused on proteins implicated in neurodegenerative diseases, Dr. Tse continued to work with Dr. Southworth as he transitioned to the Institute for Neurodegenerative Diseases at UCSF, where Dr. Tse helped establish the cryo–electron microscopy (cryo-EM) facility specialized for the IND.
Today, Dr. Tse oversees the Cryo–Electron Microscopy facility at the UCSF Institute for Neurodegenerative Diseases, maintaining and operating cutting-edge electron microscopes and dual beam focused-ion-beam scanning electron microscopes to obtain high-resolution structural data of amyloids and macromolecular complexes implicated in neurodegeneration. He provides support to the IND community, facilitating collaborative projects and exploring new avenues in cellular cryo–electron tomography to study macromolecules in their native cellular context. With a commitment to advancing structural biology, he aims to help the IND community design new approaches to unravel the mechanisms and complexities of neurodegenerative diseases.