Staff Research Associate III – Prusiner Lab

Staff Research Associate III – Prusiner Lab


Job Summary

The successful candidate will participate in developing novel cell lines to recapitulate the aggregation of prion proteins as well as developing novel cell-based assays to be used for screening chemical compounds. Additionally, the successful candidate will participate in high throughput screening (HTS) of small molecule libraries and biologicals using cell-based high content imaging (HCI) assays to identify candidate small molecule therapeutics for treating diverse neurodegenerative diseases. 

The primary responsibilities of this position are to develop novel cell lines and cell-based assays and to utilize these tools to screen small molecule libraries. This position includes hands-on lab work, especially cell culture, independently running cell-based and biochemical drug screening assays, high-content imaging of cells, handling of human and rodent tissue and Western blotting. Additionally, the candidate will be required to perform appropriate experimental planning, data analysis, documentation of results and supply management required to complete all aspects of the experimental work.

Department Description

The Institute for Neurodegenerative Diseases (IND) at UCSF is pursuing a cutting-edge blend of basic science and clinical medicine to provide outstanding care to those suffering from neurodegenerative diseases. Founded in 1999, the IND is committed to creating therapeutics that will halt diseases such as Alzheimer’s, Parkinson’s, Creutzfeldt-Jakob disease and dementia resulting from traumatic brain injuries. The IND is poised to make serious contributions to this struggle at the frontier of neuroscience and medicine. The mission of the Institute for Neurodegenerative Diseases is to discover causes and develop cures for these illnesses with an innovative program of basic research and clinical medicine.

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About UCSF

The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It is the only campus in the 10-campus UC system dedicated exclusively to the health sciences. We bring together the world’s leading experts in nearly every area of health. We are home to five Nobel laureates who have advanced the understanding of cancer, neurodegenerative diseases, aging and stem cells.

UCSF is a diverse community made of people with many skills and talents. We seek candidates whose work experience or community service has prepared them to contribute to our commitment to professionalism, respect, integrity, diversity and excellence – also known as our PRIDE values. The University of California San Francisco is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information.