For each publication, click on the title for more information, including the abstract, complete citation, and access to the article. You will be redirected to the National Library of Medicine.
Publications (most recent listed first)
A gamma-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains.
Discriminating between cellular and misfolded prion protein by using affinity to 9-aminoacridine compounds.
Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics.
Directed evolution of an anti-prion protein scFv fragment to an affinity of 1 pM and its structural interpretation.
Expression mapping of tetracycline-responsive prion protein promoter: digital atlasing for generating cell-specific disease models.
Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells.
Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein.
Recombinant prion protein induces rapid polarization and development of synapses in embryonic rat hippocampal neurons in vitro.