Publications

For each publication, click on the title for more information, including the abstract, complete citation, and access to the article. You will be redirected to the National Library of Medicine.

Publications (most recent listed first)

Gregory E Merz Matthew J Chalkley Sophia K Tan Eric Tse Joanne Lee Stanley B Prusiner Nick A Paras William F DeGrado Daniel R Southworth

Stacked binding of a PET ligand to Alzheimer's tau paired helical filaments

Carlo Condello Jacob I Ayers Clifton L Dalgard M Madhy Garcia Garcia Brianna M Rivera William W Seeley Daniel P Perl Stanley B Prusiner

Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions

Carlo Condello Gregory E Merz Atsushi Aoyagi William F DeGrado Stanley B Prusiner

Aβ and Tau Prions Causing Alzheimer's Disease

Carlo Condello...

Aβ and tau prions feature in the neuropathogenesis of Down syndrome

Daniel R Wong Jay Conrad Noah Johnson Jacob Ayers Annelies Laeremans Joanne C Lee Jisoo Lee Stanley B Prusiner Sourav Bandyopadhyay Atul J Butte Nick A Paras Michael J Keiser

Trans-channel fluorescence learning improves high-content screening for Alzheimer's disease therapeutics

Sara A M Holec Jisoo Lee Abby Oehler Felicia K Ooi Daniel A Mordes Steven H Olson Stanley B Prusiner Amanda L Woerman

Multiple system atrophy prions transmit neurological disease to mice expressing wild-type human α-synuclein

Jacob I Ayers Joanne Lee Octovia Monteiro Amanda L Woerman Ann A Lazar Carlo Condello Nick A Paras Stanley B Prusiner

Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy

George A Carlson Stanley B Prusiner

How an Infection of Sheep Revealed Prion Mechanisms in Alzheimer's Disease and Other Neurodegenerative Disorders

Terrence-Thang H Nguyen Connor J O'Brien Minh L N Tran Steven H Olson Nicholas S Settineri Stanley B Prusiner Nick A Paras Jay Conrad

Water-Soluble Iridium Photoredox Catalyst for the Trifluoromethylation of Biomolecule Substrates in Phosphate Buffered Saline Solvent

Cedric Lozano Cristian Ramirez Ny Sin Hélène M-F Viart Stanley B Prusiner Nick A Paras Jay Conrad

Silver Benzoate Facilitates the Copper-Catalyzed C-N Coupling of Iodoazoles with Aromatic Nitrogen Heterocycles

Evan Lester Felicia K Ooi Nadine Bakkar Jacob Ayers Amanda L Woerman Joshua Wheeler Robert Bowser George A Carlson Stanley B Prusiner Roy Parker

Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components

Condello C, DeGrado WF, Prusiner SB

Prion biology: implications for Alzheimer's disease therapeutics.

Ayers JI, Paras NA, Prusiner SB

Expanding spectrum of prion diseases.

Ayers JI, Prusiner SB

Prion protein - mediator of toxicity in multiple proteinopathies.

Grandjean JM, Jiu AY, West JW, Aoyagi A, Droege DG, Elepano M, Hirasawa M, Hirouchi M, Murakami R, Lee J, Sasaki K, Hirano S, Ohyama T, Tang BC, Vaz RJ, Inoue M, Olson SH, Prusiner SB, Conrad J, Paras NA

Discovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity.

Woerman AL, Patel S, Kazmi SA, Oehler A, Lee J, Mordes DA, Olson SH, Prusiner SB

Kinetics of α-synuclein prions preceding neuropathological inclusions in multiple system atrophy.

Krejciova Z, Carlson GA, Giles K, Prusiner SB

Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human α-synuclein.

Aoyagi A, Condello C, Stöhr J, Yue W, Rivera BM, Lee JC, Woerman AL, Halliday G, van Duinen S, Ingelsson M, Lannfelt L, Graff C, Bird TD, Keene CD, Seeley WW, DeGrado WF, Prusiner SB

Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain.

Woerman AL, Oehler A, Kazmi SA, Lee J, Halliday GM, Middleton LT, Gentleman SM, Mordes DA, Spina S, Grinberg LT, Olson SH, Prusiner SB

Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines.

Nick M, Wu Y, Schmidt NW, Prusiner SB, Stöhr J, DeGrado WF

A long-lived aβ oligomer resistant to fibrillization.

Condello C, Lemmin T, Stöhr J, Nick M, Wu Y, Maxwell AM, Watts JC, Caro CD, Oehler A, Keene CD, Bird TD, van Duinen SG, Lannfelt L, Ingelsson M, Graff C, Giles K, DeGrado WF, Prusiner SB

Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease.

Woerman AL, Kazmi SA, Patel S, Aoyagi A, Oehler A, Widjaja K, Mordes DA, Olson SH, Prusiner SB

Familial Parkinson's point mutation abolishes multiple system atrophy prion replication.

Johnson NR, Condello C, Guan S, Oehler A, Becker J, Gavidia M, Carlson GA, Giles K, Prusiner SB

Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice.

Lopez TP, Giles K, Dugger BN, Oehler A, Condello C, Krejciova Z, Castaneda JA, Carlson GA, Prusiner SB

A novel vector for transgenesis in the rat CNS.

Woerman AL, Patel S, Kazmi SA, Oehler A, Freyman Y, Espiritu L, Cotter R, Castaneda JA, Olson SH, Prusiner SB

Kinetics of Human Mutant Tau Prion Formation in the Brains of 2 Transgenic Mouse Lines.

Woerman AL, Kazmi SA, Patel S, Freyman Y, Oehler A, Aoyagi A, Mordes DA, Halliday GM, Middleton LT, Gentleman SM, Olson SH, Prusiner SB

MSA prions exhibit remarkable stability and resistance to inactivation.

Stöhr J, Wu H, Nick M, Wu Y, Bhate M, Condello C, Johnson N, Rodgers J, Lemmin T, Acharya S, Becker J, Robinson K, Kelly MJS, Gai F, Stubbs G, Prusiner SB, DeGrado WF

A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells.

Giles K, Woerman AL, Berry DB, Prusiner SB

Bioassays and Inactivation of Prions.

Woerman AL, Watts JC, Aoyagi A, Giles K, Middleton LT, Prusiner SB

α-Synuclein: Multiple System Atrophy Prions.

Watts JC, Prusiner SB

β-Amyloid Prions and the Pathobiology of Alzheimer's Disease.