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Alzheimer UCSF prion tau Kampmann Chen

Postdoctoral fellow John Chen in the Kampmann lab received a Research Fellowship from the Alzheimer's Association. Together with Diane Nathaniel, Dr. Chen investigates cellular pathways controlling the prion-like spread of tau aggregation, which is emerging as a key driver of disease progression in Alzheimer's disease and other neurodegenerative diseases involving tau, including frontotemporal dementia. The Kampmann lab combines CRISPR-based genetic screens with biochemistry and cell biology. The pathways identified in this project are potential therapeutic targets in Alzheimer's disease and other tauopathies.


Kampmann Lab Postdoc John Chen Named Longevity Fellow

Dr. John Chen, postdoctoral fellow in the Kampmann lab at the IND, won a QB3/Calico Longevity Fellowship. Dr. Chen works with Diane Nathaniel in the Kampmann lab to uncover cellular pathways controlling aggregation and prion-like spread of the protein tau, which is associated with Alzheimer’s disease, frontotemporal dementia, and other neurodegenerative diseases. The team is using an innovative, CRISPR-based functional genomics approach co-developed by Dr. Kampmann. The funding from the QB3/Calico program will support the implementation of these experiments in human iPSC-... Read more ...

Stepahnie See, Graduate Student, Kampmann and Gestwicki Labs

 

Stephanie See, a PhD student in the Kampmann and Gestwicki labs at the IND, was awarded the prestigious National Defense Science & Engineering Graduate (NDSEG) Fellowship. Stephanie's research is focused on the cellular mechanisms controlling the aggregation and prion-like spread of the protein alpha-synuclein, which is associated with Parkinson's disease and other neurodegenerative diseases. Her interdisciplinary project combines two innovative approaches: (1) the CRISPR/Cas9-based genetic screening technology, co-developed by IND faculty Dr. Martin Kampmann, and (2) a biochemical platform to investigate interactions with molecular chaperones, established by IND faculty Dr. Jason... Read more ...

Recognizing Scientific Excellence and Originality in the Proceedings of the National Academy of Sciences

Published in PNAS, "Evidence for α-Synuclein Prions Causing Multiple System Atrophy in Humans with Parkinsonism" has been awarded the 2015 Cozzarelli Prize by the National Academy of Sciences. The Cozzarelli Prize is given annually to six papers published in PNAS and recognizes work that demonstrates scientific excellence and originality. Authored by Stanley B. Prusiner, Amanda L. Woerman, Kurt Giles, and colleagues in the IND, the paper... Read more ...

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