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News & Articles
Neurodegenerative Diseases and Prions
Twenty-five years ago, little was known about the causes of neurodegenerative diseases. Now, however, it is clear that they result from abnormalities in the processing of proteins. In each of these diseases, defective processing causes the accumulation of one or more specific neuronal proteins.
Of all the laboratory research on neurodegenerative diseases, the studies that led to the discovery of prions have yielded the most unexpected findings. The idea that a protein can act as an infectious pathogen and cause degeneration of the central nervous system was accepted only after a long and arduous battle. The concept of prions not...
full text article from publisher:
Publisher:
Massachusetts Medical Society
Source:
The New England Journal of Medicine
Publication date:
05/17/2001