Jan Stöhr, PhD
Assistant Adjunct Professor, Department of Neurology
Dr. Stöhr investigates the structural basis for self-propagation of distinct protein conformations in prion diseases. His main focus is the induction of the prion state in vitro to form synthetic prions that display self-propagation in vivo. The formation of prions made of recombinant proteins represents the basis for producing prions in sufficient amounts for structural studies. Once formed, these prions are structurally characterized by a variety of biochemical and biophysical methods (e.g., electron microscopy and solid state NMR). Most recently, Dr. Stöhr was able to show that misfolded synthetic Aβ peptides alone are sufficient to self-propagate in vivo and hence belong to disease-associated proteins that can be present in a prion state.