Carlo Condello, PhD
Assistant Adjunct Professor, Department of Neurology
Carlo Condello received his PhD in neuroscience in 2011 from Northwestern University (Chicago, IL). His graduate work focused on understanding the kinetics and toxicity of β-amyloid deposition and the role of microglia in Alzheimer's disease (AD). Following graduation, the lab moved to Yale University, where Dr. Condello completed a project related to his thesis as a postdoctoral fellow.
In May 2012, Dr. Condello joined the Prusiner laboratory as a postdoctoral scholar, investigating the pathobiology of synthetic and naturally occurring, brain-derived AD strains. He has developed a variety of novel optical-imaging tools to decipher and catalog strains of Aβ and tau prions in the brains of AD patients and transgenic rodent models, which may have implications for developing more informative molecular diagnostics and strain-specific therapeutics. In addition, Dr. Condello developed high-resolution, noninvasive in vivo imaging methods using bioluminescent or near-infrared fluorescent reporters to monitor the kinetics of disease progression in mouse and rat models of AD and PrP prion disease.
In March 2015, Dr. Condello was appointed Assistant Professor in the IND, where he continues to study AD prion strains at the molecular and cellular levels with innovative imaging strategies in animal models. In collaboration with medicinal chemists, he also works on screening and developing novel small-molecule imaging probes to monitor the accumulation of pathological protein aggregates in patients with AD, frontotemporal dementia, and chronic traumatic encephalopathy.