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Latest Findings
- Spontaneous generation of anchorless prions in transgenic mice
Some prion protein mutations create anchorless molecules that cause Gerstmann-Sträussler-Scheinker (GSS) disease. To model GSS, we generated transgen...
read the complete article - Protease-resistant prions selectively decrease shadoo protein
The central event in prion diseases is the conformational conversion of the cellular prion protein (PrP(C)) into PrP(Sc), a partially protease-resista...
read the complete article
Institute for Neurodegenerative Disease
Understanding Our Work
America is now facing an epidemic of dementia. Alzheimer's disease affects 5 million Americans. While the human cost is incalculable, the financial burden of caring for these patients is now $150 billion a year. And the crisis is spreading. Close to half of us will have Alzheimer's by the time we reach 85.
See what we are doing about it