Xu Ran, PhD
Postdoctoral Scholar, Gestwicki Lab
Xu Ran received his PhD in 2015 from the Department of Medicinal Chemistry at the University of Michigan, Ann Arbor, under the supervision of Dr. Shaomeng Wang. Dr. Ran's graduate work focused on using stapled peptide or nonpeptide small molecules to target oncogenic protein-protein interactions for the treatment of cancer. Dr. Ran received extensive training in medicinal chemistry during his doctoral studies, including drug design, solid phase peptide synthesis, small-molecule organic synthesis, high-throughput screening, protein crystallography, and cancer biology.
As a postdoctoral scholar in the Gestwicki laboratory, Dr. Ran continues to work on inhibitors for protein-protein interactions. Instead of making new drug candidates for well-explored protein-protein interfaces, he is working on targets that are traditionally considered "undruggable." He also extends his interests to protein chaperone mechanisms, biochemical assay development, and drug target identification for neurodegenerative diseases. One of his projects is making new hsp70 inhibitors for the therapeutics of cancer or neurodegenerative disease.