Xiaoyan Guo, PhD
Postdoctoral Scholar, Kampmann Lab
Xiaoyan Guo received her PhD in 2014 at Texas A&M University. Under the supervision of Dr. Luis Rene Garcia, Dr. Guo’s graduate work focused on the mechanisms of behavioral deterioration in early aging male C. elegans.
Dr. Guo’s current research aims to understand the interplay between mitochondrial dysfunction and alpha-synuclein aggregation in Parkinson’s disease. PD is the second most common neurodegenerative disease and the most prevalent progressive movement disorder among the elderly. So far, there is no cure for PD because of the lack of mechanistic understanding necessary for developing effective therapies. Human genetics and studies in experimental model systems have linked both mitochondrial dysfunction and alpha-synuclein aggregation to PD. Although there are several lines of evidence showing that these two interact with each other, it is still mysterious how mitochondrial dysfunction promotes alpha-synuclein aggregation and, vice versa, how alpha-synuclein aggregation leads to mitochondrial dysfunction.